Replication and translation of epigenetic information

• Antragstellerin: Professorin Dr. Maria Cristina Cardoso
• Fachliche Zuordnung: Zellbiologie
• Förderung: Förderung von 2003 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5407439

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

The goal was to investigate the role of MeCPs in establishing and translating epigenetic information. We addressed how MeCPs and interacting factors affect the spatial/functional organization of the genome and whether this influences the accessibility and mobility of proteins.

Projektbezogene Publikationen (Auswahl)

• Replication-independent chromatin loading of Dnmt1 during G2 and M phases EMBO Rep (2004) 5: 1181-1186
  H. P. Easwaran, L. Schermelleh, H. Leonhardt & M. C. Cardoso
  
• Cell Cycle Markers for Live Cell Analyses Cell Cycle (2005) 4: 53-55
  H. P. Easwaran, H. Leonhardt & M. C. Cardoso
  
• Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation J Cell Biol (2005) 169: 733-743
  A. Brero, H. P. Easwaran, D. Nowak, I. Grunewald, T. Cremer, H. Leonhardt, and M. C. Cardoso
  
• Replication and Translation of Epigenetic Information CTMI (2006)
  A. Brero, H. Leonhardt, M. C. Cardoso
  
• MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation Nucl Acids Res (2007) 35: 5402-5408
  N. Aganwal, T. Hardt, A. Brero, D. Nowak, U. Rothbauer, A. Becker, H. Leonhardt & M. C. Cardoso
  
• Probing Intranuclear Environments at the Single-Molecule Level Biophys J (2008) 94: 2847-2858
  D. Grünwald, R. M. Martin, V. Buschmann, D. P. Bazett-Jones, H. Leonhardt, U. Kubitscheck & M. C. Cardoso