Bedeutung von Histamin in der Pathogenese von fibrotischen Lungenerkrankungen mit Aufklärung möglicher cross-talks in den Signaltransduktionswegen von TGF-beta1 und Histamin

Applicant Professor Dr. Steffen Kunzmann

Subject Area Pediatric and Adolescent Medicine

Term from 2004 to 2008

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 5410591

Final Report Year 2008

Final Report Abstract

No abstract available

Antenatal inflammation induced TGF-ß1 but suppressed CTGF in preterm lungs. Am J Physiol Lung Cell Mol Physiol 292: L112-231, 2006
Kunzmann S, Speer C, Jobe AH, and Kramer BW
TGF-ßl in SP-A preparations influence immune suppressive properties of SP-A on human CD4+ T lymphocytes. Am JPhysiol Lung Cell Mol Physiol 291: L747-756, 2006
Kunzmann S, Wright JR, Steinhilber W, Kramer BW, Blaser K, Speer CP, Schmidt-Weber C
Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: Potential role of histamine in airway remodelling. J Allergy Clin Immunol. 119 (6): 1398- 1407,2007
Kunzmann S, Schmidt-Weber C, Zingg JM, Azzi A, Kramer BW, Blaser K, Akdis CA, Speer CP
Connective Tissue Growth Factor Does Not Affect Transforming Growth Factor-ßl- Induced Smad3 Phosphorylation and T Lymphocyte Proliferation Inhibition. Int Arch Allergy Immunol 147: 152-160,2008
S. Kunzmann, A. Seher, B.W. Kramer. R. Wagemanns, N. Schütze, F. Jakob, W. Sebald, C.P. Speer