Project Details
Projekt
Disturbed proteoglycan homeostasis drives pulmonary hypertension in lung fibrosis (A11*)
Subject Area
Pneumology, Thoracic Surgery
Term
since 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 268555672
The presence of pulmonary hypertension (PH) in lung fibrosis (PF) leads to increased morbidity. Basement membrane (BM) components such as proteoglycans (PGs) affect all aspects of cell life including proliferation, differentiation, mechanical properties, and production of mediators controlling inflammation and coagulation. We will investigate spatial and temporal localization/dynamics of PGs and their therapeutic potential in PH-PF lungs and respective animal models. On the cellular level, we will delineate mechanistic and coagulatory properties of PGs and characterize their impact on bidirectional communication between endothelial and vascular smooth muscle cells. Our studies thus aim to identify the fundamental molecular and translational aspects of PGs in PH-PF.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1213:
Pulmonary Hypertension and Cor Pulmonale
Applicant Institution
Justus-Liebig-Universität Gießen
