Detailseite
Projekt
Lymphangiogenesis and hemangiogenesis: Common molecular determinants?
Antragsteller
Professor Dr. Jörg Wilting
Fachliche Zuordnung
Pathologie
Förderung
Förderung von 2003 bis 2008
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5417869
The embryonic origin of lymphatic endothelial cells (LECs) is still a matter of controversy. It has often been suggested that LECs develop by sprouting from specialized parts of the deep embryonic veins. However, descriptive and experimental studies have shown that lymphatics also develop independently from the deep embryonic veins and in close association with hematopoietic cells. This suggests that in the embryo bipotential hem-lymphangioblasts exist, whose localization and differentiation potential have not been investigated. This will be studied by means of cell lineage experiments in the first part of our project. In the blood islands of the yolk sac, blood vascular endothelial cells (BECs) and the first generation of blood cells develop from a common hemangioblast. The second definitive generation of hematopoietic cells, which then also produces the leukopoietic lineages, develops temporally and spatially in close relation to the lymphatics. In the second part of our project we will study if the genes that control the development of hemangioblasts and hematoblasts also control the development of lymphangioblasts.
DFG-Verfahren
Schwerpunktprogramme
Beteiligte Person
Professor Dr. Lothar L. Schweigerer
