SPP 1069:  Angiogenese: Molekulare Mechanismen und funktionelle Interaktionen

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 1999 bis 2006
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5469369

Keine Zusammenfassung vorhanden

• DFG-Verfahren: Schwerpunktprogramme
• Internationaler Bezug: Frankreich, Niederlande, Schweden, Schweiz, USA

Projekte

• Analysis of lymphangiogenesis during tumorigenesis, wound healing, lymphedema and filariasis (Antragsteller Sleeman, Jonathan Paul )
• Characterisation of Ras as a master switch in angiogenesis and analysis of VEGFR1/Flt-1 function by selective activation of its intracellular domain (Antragsteller Heumann, Rolf )
• Chemoattractants as mediators between shear force changes, macrophage activation and collateral proliferation (Antragsteller Ito, Wulf D. )
• Choroidal neovascularization: Effects of CXC chemokines and growth factors mediated by "advanced glycated endproducts" (AGE) (Antragsteller Wiedemann, Peter )
• Conditional alpha-v integrin gene knockout in mice: Functional analysis of alpha-v integrins during blood vessel formation in physiological and pathological situations (Antragsteller Bader, Bernhard )
• Contribution of the Tie/Angiopoietin receptor/ligand system to growth, morphology and function of blood vessels in adult mice (Antragsteller Deutsch, Urban )
• Design and development of a recombinant antibody to block ligand sFlt-1 interaction for an animal model of preeclampsia (Antragsteller Weich, Herbert A. )
• Endothelial cell intrinsic function of HIF-1 alpha and HIF-2 alpha in physiological and pathological conditions (Antragsteller Plate, Karlheinz )
• Functional Analysis of Endothelial Cells during Angiogenesis (Antragsteller Augustin, Hellmut G. )
• Functional analysis of the lymphatic system in normal and diseased tissue (Antragsteller Hawighorst, Thomas )
• Functional analysis of the lymphatic system in normal and diseased tissue (Antragsteller Koch, Manuel )
• Gewebe-spezifische Inaktivierung des VEGF (Vascular endothelial growth factor) Gens im Zentralnervensystem der Maus (Antragsteller Breier, Georg )
• Identification of VEGF-induced signaling events involved in angiogenesis and vascular permeability (Antragsteller Clauss, Ph.D., Matthias )
• Identifizierung der molekularen Mechanismen der Onkogen-induzierten, Sp 1 vermittelten Aktivierung des VEGF Promotors (Antragsteller Finkenzeller, Günter )
• Impact of the tumor suppressor gene DPC4/SMAD4 on regulators of angiogenesis (Antragstellerin Schwarte-Waldhoff, Irmgard )
• Interleukin-6 as an N-myc regulated angiogenesis inhibitor: mechanisms and clinical implications (Antragsteller Schweigerer, Lothar L. )
• Investigation of the district-specific influence of vascular endothelial growth factor (VEGF165) on arteriogenesis/angiogenesis of arteries of distinct developmental origin including proteomics analyses (Antragstellerin Nikol, Sigrid )
• Koordinatorfonds (Antragsteller Augustin, Hellmut G. )
• Lymphangiogenesis and hemangiogenesis: Common molecular determinants? (Antragsteller Wilting, Jörg )
• Mechanism of ephrinB2 reverse signaling during angiogenesis (Antragsteller Klein, Rüdiger )
• Molekulare Charakterisierung von pathogenkodierten Angiogenesefaktoren (Antragsteller Dehio, Christoph )
• Pathophysiologic and therapeutic significance of EphrinB2/EphB4 for angiogenesis, microcirculation, and growth of malignant brain tumors (Antragsteller Vajkoczy, Peter )
• Pathophysiologic and therapeutic significance of EphrinB2/EphB4 for angiogenesis, microcirculation, and growth of malignant brain tumors (Antragsteller Ullrich, Axel )
• Recruitment and activation mechanisms of embryonic endothelial progenitor cells in neovascularization (Antragsteller Hatzopoulos, Antonis K. )
• Regulation of pericytes by Angiopoietin2-studies in new animal models (Antragsteller Hammes, Hans-Peter )
• Role of Matrix Metalloproteinases in the Regulation of Tumor Angiogenesis and Invasion (Antragsteller Fusenig, Norbert E. )
• Role of VEGF in arteriogenesis (Antragsteller Waltenberger, Johannes )
• The endothelial cholinergic system: significance for endothelial cell differentiation and angiogenesis (Antragstellerin Kräling, Birgit )
• The influence of endothelial cell specific transcriptional regulators (HIF-2 alpha, ets-1) on vasculogenesis and embryonic angiogenesis in vivo (Antragsteller Breier, Georg )
• The Role of CEACAM1 (CEA-related cell adhesion molecule 1) in vascular morphogenesis and stabilization (Antragsteller Ergün, Süleyman )
• Therapeutic Coronary Angiogenesis and Arteriogenesis Induced by Retroinfusion of Liposomal cDNA encoding for eNOS S1177D: Comparison to fluid shear stress (FSS) induction (Antragsteller Boekstegers, Peter )
• Transcriptional regulation of endothelial cell specific angiopoietin-2 expression (Antragstellerin Fiedler, Ulrike )

• Sprecher: Professor Dr. Hellmut G. Augustin