Thyroid Hormone Receptor Corepressors: Requirements and Selectivity for Histone Modifications Cell Culture

• Antragsteller: Professor Dr. Aria Baniahmad
• Fachliche Zuordnung: Allgemeine Genetik und funktionelle Genomforschung
• Förderung: Förderung von 2004 bis 2011
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5470729

Thyroid hormone (T3) is an important regulator of neuronal differentiation and maturation. The receptor for thyroid hormone (TR) is a ligand regulated transcription factor mediating both gene repression and activation. A number of different corepressors have been described to interact with TR. Corepressors bind either in a hormone-sensitive, hormone-independent or hormone-dependent manner to TR. However, it is not understood which biological functions individual corepressors play in the context of TR-mediat ed gene repression and activation as well as for TR-mediated neuronal differentiation and maturation. This project analyses the selectivity and specificity of corepressors in the context of chromatin through histone modifications (acetylation, methylation, phosphorylation and ubiquitinylation) of TR target genes as well as the impact of corepressors on neuronal differentiation and maturation.

• DFG-Verfahren: Forschungsgruppen
• Teilprojekt zu: FOR 531: Chromatin Mediated Biological Decisions