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Projekt Druckansicht

Substrattransport durch die äußere Membran von Caulobacter crescents

Fachliche Zuordnung Stoffwechselphysiologie, Biochemie und Genetik der Mikroorganismen
Förderung Förderung von 2004 bis 2007
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5468788
 
The genome sequence of Caulobacter crescentus (Cc) predicts an unusually high number of outer membrane proteins of which most (67) are proposed to transport nutrients energy-coupled via the Ton system into cells. The habitat of Cc (lakes and rivers) usually contains very low concentrations of nutrients of which insufficient amounts may pass through the outer membrane by diffusion. The project will examine the prediction of TonB coupled transport for a number of nutrients (sugars, oligosaccharides, amino sugars, amino acids, peptides, nucleosides) and characterize the role TonB plays in nutrient uptake. If the prediction of TonB coupled transport turns out to be wrong for most of the proteins, we will study a few uptake systems to find out why the Cc proteins have more than double the size of hitherto characterized porins.
DFG-Verfahren Forschungsgruppen
 
 

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