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Einfluss von Schwermetallen (Zink) auf die Pathogenität von Salmonella enterica pv. Typhimurium
Antragstellerin
Dr. Sylvia Franke
Fachliche Zuordnung
Stoffwechselphysiologie, Biochemie und Genetik der Mikroorganismen
Förderung
Förderung von 2004 bis 2006
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5434865
In my research I will investigate the role of metals other than iron in bacterial virulence. There are many pathogenic microorganisms that require metals for virulence including Mycobacterium tuberculosis, Neisseria meningitis and Salmonella enterica. I will first employ Salmonella as a model organism because it is easily genetically manipulated. Salmonella enterica pv. Typhimurium has a broad host range and it is for example responsible for human gastroenteritis. In the mouse model S. enterica pv. Typhimurium can serve as a model for typhoid fever caused by S. enterica pv. Typhi in humans. The role of different trace elements, such as iron and manganese, on virulence of S. enterica pv. Typhimurium are partially well investigated. Starting to understand the role of zinc in virulence of S. enterica pv. Typhimurium, the frist goals are: i) characterization the role of zinc transporters in infection and survival, ii) starting identification and characterization of Zn2+-dependent enzymes involved in virulence, and iii) characterization of ZupT (determining membrane topology and characterization of ZupT mediated metal transport).
DFG-Verfahren
Forschungsstipendien
Internationaler Bezug
USA
Kooperationspartner
Professor Dr. Christopher Rensing