Die Funktion von Podocin bei der Rekrutierung von Schlitzmembranproteinen - Bedeutung in der Pathogenese des nephrotischen Syndroms

• Applicant: Professor Dr. Thomas Benzing
• Subject Area: Nephrology
• Term: from 2004 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5436464

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in vitro and in vivo. Kidney Int. 77:690-9
  Brinkkoetter, P.T., J.S. Wu, T. Ohse, R.D. Krofft, B. Schermer, T. Benzing, J.W. Pippin, and S.J. Shankland
  
• 2005. The slit diaphragm: a signaling platform to regulate podocyte function. Curr Opin Nephrol Hypertens. 14:211-6
  Huber, T.B., and T. Benzing
  
• 2006. Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci USA. 103:17079-86
  Huber, T.B., B. Schermer, R.U. Muller, M. Hohne, M. Bartram, A. Calixto, H. Hagmann, C. Reinhardt, F. Koos, K. Kunzelmann, E. Shirokova, D. Krautwurst, C. Harteneck, M. Simons, H. Pavenstädt, D. Kerjaschki, C. Thiele, G. Walz, M. Chalfie, and T. Benzing
  
• 2007. Podocin organizes ion channellipid supercomplexes: implications for mechanosensation at the slit diaphragm. Nephron Exp Nephrol. 106:e27-31
  Huber, T.B., B. Schenner, and T. Benzing
  
• 2008. KIBRA modulates directional migration of podocytes. J Am Soc Nephrol. 19:1891-903
  Duning, K., E.M. Schurek, M. Schluter, M. Bayer, H.C. Reinhardt, A. Schwab, L. Schaefer, T. Benzing, B. Schermer, M.A. Saleem, T.B. Huber, S. Bachmann, J. Kremerskothen, T. Weide, and H. Pavenstädt
  
• 2008. Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol. 19:2150-8
  Harvey, S.J., G. Jarad, J. Cunningham, S. Goldberg, B. Schermer, B.D. Harfe, M.T. McManus, T. Benzing, and J.H. Miner
  
• 2009. Lipid-protein interactions along the slit diaphragm of podocytes. J Am Soc Nephrol. 20:473-8
  Schermer, B., and T. Benzing