Maintenance and modification of epigenetic information: Coordination of DNA replication and methylation during the cell cycle and in development

• Antragsteller: Professor Dr. Heinrich Leonhardt
• Fachliche Zuordnung: Zellbiologie
• Förderung: Förderung von 2004 bis 2012
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5437638

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2004). Replication independent chromatin loading of Dnmt1 during G2 and M phases. EMBO Rep., 5: 1181- 1186
  Easwaran, H. P., Schermelleh, L., Leonhardt, H. and Cardoso, M. C.
  
• (2005) Restricted mobility of Dnmt1 in early embryos: implications for epigenetic reprogramming. BMC Dev. Biol., 5: 18
  Grohmann, M., Spada, F., Schermelleh. L., Alenina, N., Bader, M., Cardoso, M. C. and Leonhardt, H.
  
• (2005). Cell cycle markers for live cell analyses. Cell Cycle, 4: 453-455
  Easwaran, H. P., Leonhardt, H. and Cardoso, M. C.
  
• (2005). Recruitment of DNA methyltransferase I to DNA repair sites. PNAS. 102, 8905-8909
  Mortusewicz, O., Schermelleh, L., Walter, J., Cardoso, M. C. and Leonhardt, H.
  
• (2009). DNA methylation-mediated epigenetic control. J. Cell. Biochem. (Epub ahead of print)
  Rottach, A., Leonhardt, H. and Spada, F.
  
• 2005). Trapped in action - direct visualization of Dnmt1 activity in living cells. Nature Methods, 2, 751-756
  Schermelleh, L., Spada, F., Easwaran, H. P., Zolghadr, K., Margot, J. B., Cardoso, M. C. and Leonhardt, H.
  
• (2006) Regulation of DNA methyltransferase 1. Adv. Enzym Regul., 46, 224-34
  Spada, F., Rothbauer, U., Zolghadr, K., Schermelleh, L., Leonhardt, H.
  
• (2007). DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J. Cell Biol. 176, 565-71
  Spada, F., Haemmer, A., Kuch, D., Rothbauer, U., Schermelleh, L., Kremmer, E., Carell, T., Längst, G. and H. Leonhardt
  
• (2007). Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation. Nucl. Acids Res. 35, 4301-12
  Schermelleh, L., Haemmer, A., Spada, F., Rosing, N., Meilinger, D., Rothbauer, U., Cardoso, M. C. and H. Leonhardt
  
• (2008). A fluorescent two-hybrid (F2H) assay for direct visualization of protein interactions in living cells. Mol. Cell. Proteomics, 7, 2279-87
  Zolghadr, K., Mortusewicz, O., Rothbauer, U., Kleinhans, R., Göhler, H., Wanker, E., Cardoso, M.C. and Leonhardt, H.
  
• (2008). Spatiotemporal dynamics of regulatory protein recruitment at DNA damage sites. J. Cell. Biochem., 104, 1562-9
  Mortusewicz O, Leonhardt H. and Cardoso M.C.
  
• (2009) Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain. J. Cell. Biochem., 106, 521- 8
  Fellinger, K., Rothbauer, U., Felle, M., Längst, G. and Leonhardt, H.
  
• (2009) MBD4 and MLH1 are required for apoptotic induction in xDnmt1-depleted embryos. Development, 136, 2277-86
  Ruzov, A., Shorning, B., Mortusewicz, O., Dunican, D. S., Leonhardt, H., and Meehan, R.