Der Einfluss genetischer Risikofaktoren auf die Ausprägung pathologischer Merkmale des Morbus Alzheimer

• Antragsteller: Privatdozent Dr. Estifanos Ghebremedhin
• Fachliche Zuordnung: Klinische Neurologie; Neurochirurgie und Neuroradiologie
• Förderung: Förderung von 2005 bis 2011
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5439162

• Erstellungsjahr: 2010

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2005) Apolipoprotein E co-localizes with newly formed amyloid beta-protein (A beta) deposits lacking immunoreactivity against N-terminal epitopes of A beta in a genotype-dependent manner. Acta Neuropathol 110:459-471
  Thal DR, Capetillo-Zarate E, Schultz C, Rüb U, Saido TC, Yamaguchi H, Haass C, Griffin WST, Del Tredici K, Braak H, Ghebremedhin E
  
• (2006) Cerebral amyloid angiopathy and cortical microinfarcts as putative substrates of vascular dementia. Int J Geriatr Psychiatry 21:681-687
  Haglund M, Passant U, Sjöbeck M, Ghebremedhin E, Englund E
  
• (2006) Relationship of Apolipoprotein E and age at onset to Parkinson disease neuropathology. J Neuropathol Exp Neurol 65:116-123
  Ghebremedhin E, Del Tredici K, Vuksic M, Rüb U, Thal DR, Burbach GJ, Rosenberger A, Bickeböller H, Deller T, de Vos RAI, Jansen Steur ENH, Braak H
  
• (2006) The intronic deletion polymorphism of the a2-macroglobulin gene modulates the severity and extent of atherosclerosis in the circle of Willis. Neuropathol Appl Neurobiol 32:451-454
  Larionov S, Dedeck O, Birkenmeier G, Orantes M, Ghebremedhin E, Thal DR
  
• (2007) Homozygosity for the K variant of BCHE gene increases the risk for development of neurofibrillary pathology but not amyloid deposits at young ages. Acta Neuropathol 114:359-363
  Ghebremedhin E, Thal DR, Schultz C, Braak H, Deller T
  
• (2007) Risikofaktoren der Alzheimer-Krankheit - was verraten uns die Gene? Forschung Frankfurt 2/2007, p90-93
  Ghebremedhin E, Deller T
  
• (2007) Vessel ultrastructure in APP23 transgenic mice after passive anti-Aβ immunotherapy and subsequent intracerebral hemorrhage. Neurobiol Aging 28:202-212
  Burbach GJ, Vlachos A, Ghebremedhin E, Del Turco D, Coomaraswamy J, Staufenbiel M, Jucker M, Deller T
  
• (2008) Alzheimer Pathogenesis for Men and Women. Alzheimer's Disease Research Journal 2: 39-52
  Corder EH, Ghebremedhin E, Thal DR, Ohm TG, Braak H
  
• (2008) Alzheimer Pathogenesis for Men and Women. In: Anouk M. Visser (ed) Alzheimer's Disease: New Research. Nova Biomedical, pp 165-180
  Corder EH, Ghebremedhin E, Thal DR, Ohm TG, Braak H
  
• (2008) Cerebral amyloid angiopathy and its relationship to Alzheimer's disease. Acta Neuropathol 115:599-609
  Thal DR, Griffin WS, de Vos RA, Ghebremedhin E
  
• (2008) Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes. J Neuropathol Exp Neurol 67:842-56
  Utter S, Tamboli IY, Walter J, Upadhaya AR, Birkenmeier G, Pietrzik CU, Ghebremedhin E, Thal DR