Further analysis of MK5 deficient mice: Role of MK5/ERK3/4 signalling in tumor suppression and neuronal functions

• Applicant: Dr. Alexey Kotlyarov
• Subject Area: Cell Biology
• Term: from 2004 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5441674

• Final Report Year: 2016

No abstract available

Publications

• (2010) MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin. Biochemical pharmacology 80: 1915-1920
  Ronkina N, Menon MB, Schwermann J, Tiedje C, Hitti E, Kotlyarov A, Gaestel M
  
• (2010) Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins. Biochemical Society transactions 38: 1632-1637
  Tiedje C, Kotlyarov A, Gaestel M
  
• (2010) p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. The Journal of biological chemistry 285: 33242-33251
  Menon MB, Schwermann J, Singh AK, Franz-Wachtel M, Pabst O, Seidler U, Omary MB, Kotlyarov A, Gaestel M
  
• (2011) Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3. The Journal of biological chemistry 286: 24113-24124
  Ehlting C, Ronkina N, Bohmer O, Albrecht U, Bode KA, Lang KS, Kotlyarov A, Radzioch D, Gaestel M, Haussinger D, Bode JG
  
• (2011) SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition. PloS one 6: e23054
  Menon MB, Kotlyarov A, Gaestel M
  
• (2011) Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes. Nucleic acids research 39: 2503-2518
  Ronkina N, Menon MB, Schwermann J, Arthur JS, Legault H, Telliez JB, Kayyali US, Nebreda AR, Kotlyarov A, Gaestel M
  
• (2012) Small-molecule protein and lipid kinase inhibitors in inflammation and specific models for their evaluation. Methods in molecular biology 795: 35-44
  Gaestel M, Kotlyarov A
  
• (2012) The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology. Molecular and cellular biology 32: 2467-2478
  Brand, Frank; Schumacher, Stefanie; Kant, Shashi; Menon, Manoj B.; Simon, Ruth; Turgeon, Benjamin; Britsch, Stefan; Meloche, Sylvain; Gaestel, Matthias & Kotlyarov, Alexey
  
• (2012) The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation. PLoS genetics 8: e1002977
  Tiedje, Christopher; Ronkina, Natalia; Tehrani, Mohammad; Dhamija, Sonam; Laass, Kathrin; Holtmann, Helmut; Kotlyarov, Alexey & Gaestel, Matthias
  
• (2013) Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFalpha production. The Biochemical journal 456: 163-172
  Menon, Manoj B.; Tiedje, Christopher; Lafera, Juri; Ronkina, Natalia; Konen, Timo; Kotlyarov, Alexey & Gaestel, Matthias
  
• (2014) Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. PLoS genetics 10: e1004558
  Menon, Manoj B.; Sawada, Akihiro; Chaturvedi, Anuhar; Mishra, Pooja; Schuster-Gossler, Karin; Galla, Melanie; Schambach, Axel; Gossler, Achim; Förster, Reinhold; Heuser, Michael; Kotlyarov, Alexey; Kinoshita, Makoto & Gaestel, Matthias
  
• (2015) p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex. Rna 21: 262-278
  Tiedje, Christopher; Lubas, Michal; Tehrani, Mohammad; Menon, Manoj B.; Ronkina, Natalia; Rousseau, Simon; Cohen, Philip; Kotlyarov, Alexey & Gaestel, Matthias
  
• (2015) Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK. PloS one 10: e0136138
  Ronkina, Natalia; Johansen, Claus; Bohlmann, Lisa; Lafera, Juri; Menon, Manoj B.; Tiedje, Christopher; Laaß, Kathrin; Turk, Benjamin E.; Iversen, Lars; Kotlyarov, Alexey & Gaestel, Matthias
  
• (2015) The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis. Journal of immunology 195: 541-552
  Soukup, Klara; Halfmann, Angela; Le Bras, Marie; Sahin, Emine; Vittori, Sarah; Poyer, Fiona; Schuh, Cornelia; Luger, Romana; Niederreiter, Birgit; Haider, Thomas; Stoiber, Dagmar; Blüml, Stephan; Schabbauer, Gernot; Kotlyarov, Alexey; Gaestel, Matthias; Felzmann, Thomas & Dohnal, Alexander M.
  
• (2015) The problem of pyridinyl imidazole class inhibitors of MAPK14/p38alpha and MAPK11/p38beta in autophagy research. Autophagy 11: 1425- 1427
  Menon, Manoj B; Dhamija, Sonam; Kotlyarov, Alexey & Gaestel, Matthias
  
• (2016) GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis. Scientific reports 6: 20007
  Abbey, Megha; Hakim, Cosima; Anand, Roopsee; Lafera, Juri; Schambach, Axel; Kispert, Andreas; Taft, Manuel H.; Kaever, Volkhard; Kotlyarov, Alexey; Gaestel, Matthias & Menon, Manoj B.