Die Rolle von IGFBP-2 bei der Entstehung und Progression des Kolonkarzinoms

• Antragsteller: Professor Dr. Eckhard Wolf, seit 7/2006
• Fachliche Zuordnung: Gastroenterologie
• Förderung: Förderung von 2005 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5397571

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (1994). Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth. Endocrinology 135, 1877-1886
  Wolf,E., Kramer,R., Blum,W.F., Foll,J., and Brem,G.
  
• (1998). Insulin-like growth factor-binding protein-2 inhibits proliferation of human embryonic kidney fibroblasts and of IGF-responsive colon carcinoma cell lines. FEBS Lett. 434, 329-334
  Hoflich,A., Lahm,H., Blum,W., Kolb,H., and Wolf,E.
  
• (1999). Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain. Endocrinology 140, 5488-5496
  Hoeflich,A., Wu,M., Mohan,S., Foll,J., Wanke,R., Froehlich,T., Arnold,G.J., Lahm,H., Kolb,H.J., and Wolf,E.
  
• (2001). Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2. Endocrinology 142, 1889-1898
  Hoeflich,A., Nedbal,S., Blum,W.F., Erhard,M., Lahm,H., Brem,G., Kolb,H.J., Wanke,R., and Wolf,E.
  
• (2001). Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter? Cancer Res. 61, 8601-8610
  Hoeflich,A., Reisinger,R., Lahm,H., Kiess,W., Blum,W.F., Kolb,H.J., Weber,M.M., and Wolf,E.
  
• (2002). Mutation of the RGD sequence does not affect plasma membrane association and growth inhibitory effects of elevated IGFBP-2 in vivo. FEBS Lett. 523, 63-67
  Hoeflich,A., Reisinger,R., Vargas,G.A., Elmlinger,M.W., Schuett,B., Jehle,P.M., Renner-Muller,I., Lahm,H., Russo,V.C., and Wolf,E.
  
• (2004). Insulin-like growth factor (IGF)-binding protein-4 inhibits colony formation of colorectal cancer cells by IGF-independent mechanisms. Cancer Res. 64, 1600-1603
  Diehl,D., Hoeflich,A., Wolf,E., and Lahm,H.
  
• (2005). Transcriptome analysis of a human colorectal cancer cell line shows molecular targets of insulin-like growth factor-binding protein-4 overexpression. Int. J Cancer 113, 588-599
  Diehl,D., Lahm,H., Wolf,E., and Bauersachs,S.
  
• (2006). IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment. J Carcinog. 5, 24
  Diehl,D., Oesterle,D., Elmlinger,M.W., Hoeflich,A., Wolf,E., and Lahm,H.
  
• (2009). IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis. Int. J. Cancer 124, 2220-2225
  Diehl,D., Hessel,E., Oesterele,D., Renner-Müller,I., Elmlinger,M., Langhammer,M., Göttlicher,M., Wolf,E., Lahm,H. and Hoeflich,A.