Zentrales Gemeinschaftsprojekt Genomics, Proteomics, Organisation

• Antragsteller: Professor Dr. Burkhard Göke
• Fachliche Zuordnung: Gastroenterologie
• Förderung: Förderung von 2005 bis 2008
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5397571

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Assessing quantitative post-mortem changes in the gray matter of the human frontal cortex proteome by 2-D DIGE. Proteomics 8, 1276-1291
  Crecelius,A., Götz,A., Arzberger,T., Fröhlich,T., Arnold,G.J., Ferrer,I., Kretzschmar,H.A.
  
• Invasion of tumorigenic HT1080 cells is impeded by blocking or downregulating the 37-kDa/67-kDa laminin receptor. J Mol Biol. 378, 530-539
  Zuber,C., Knackmuss,S., Zemora,G., Reusch,U., Vlasova,E., Diehl,D., Mick,V., Hoffmann,K., Nikles,D., Fröhlich,T., Arnold,G.J., Brenig,B., Wolf,E., Lahm,H., Little,M., Weiss,S.
  
• The brain proteome profile is highly conserved between Prnp-/-and Prnp+/+mice. Neuroreport. 19, 1027-1031
  Crecelius,A.C., Helmstetter,D., Strangmann,J., Mitteregger,G., Fröhlich,T., Arnold,G.J., Kretzschmar,H.A.
  
• (2005). DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells. Journal of Biological Chemistry 280, 7962-7975
  Bommer,G.T., Jager,C.J., Durr,E.M., Baehs,S., Eichhorst S.T., Brabletz,T., Hu,G., Frohlich,T., Arnold,G., Kress,D.C., Goke,B., Fearon,E.R., and Kolligs,F.T.
  
• (2005). Functional genomics: tools for improving farm animal health and welfare. Rev Sci Tech 24, 355-377
  Hiendleder, S., Bauersachs, S., Boulesteix, A., Blum, H., Arnold, G. J., Frohlich, T. und Wolf, E.
  
• (2005). Gene expression profiling of bovine endometrium during the oestrous cycle: detection of molecular pathways involved in functional changes. J Mol Endocrinol 34, 889-908
  Bauersachs, S., Ulbrich, S. E., Gross, K., Schmidt, S. E., Meyer, H. H., Einspanier, R., Wenigerkind, H., Vermehren, M., Blum, H., Sinowatz, F. und Wolf, E.
  
• (2005). Holistic differential analysis of embryo-induced alterations in the proteome of bovine endometrium in the preattachment period. Proteomics 5, 2551-2560
  Berendt,F.J., Frohlich,T., Schmidt,S.E.M., Reichenbach,H.D., Wolf,E., and Arnold.G.J.
  
• (2005). Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein - Absolute quantification using isotope-coded tags and mass spectrometry. Journal of Biological Chemistry 280, 2536-2542
  Hochleitner,E.O., Kastner,B., Frohlich,T., Schmidt,A., Luhrmann,R., Arnold,G., and Lottspeich,F.
  
• (2006). [Methods for transcriptome and proteome research: applications for studying the biology of reproduction in cattle]. Berl Munch Tierarztl Wochenschr 119, 7-16
  Wolf, E., Hiendleder, S., Bauersachs, S., Frohlich, T., Sinowatz, F., Blum, H. und Arnold, G. J.
  
• (2006). Analysis of the HUPO Brain Proteome reference samples using 2-D-DIGE and 2-D LC-MS/MS. Proteomics 6, 4950-4966
  Frohlich,T., Helmstetter,D., Zobawa,M., Crecelius,A.C, Arzberger,T., Kretzschmar,H.A., and Arnold,G.J.
  
• (2006). Embryo-induced transcriptome changes in bovine endometrium reveal species-specific and common molecular markers of uterine receptivity. Reproduction 132, 319-331
  Bauersachs, S., Ulbrich, S. E., Gross, K., Schmidt, S. E., Meyer, H. H., Wenigerkind, H., Vermehren, M., Sinowatz, F., Blum, H. und Wolf, E.
  
• (2006). HUPO Brain Proteome Project: Summary of the pilot phase and introduction of a comprehensive data reprocessing strategy. Proteomics 6, 4890-4898
  Hamacher,M., Apweiler,R., Arnold,G., Becker,A., Bluggel,M., Carrette,O., Colvis,C., Dunn,M.J., Frohlich,T., Fountoulakis,M., van Hall,A., Herberg,F., Ji,J., Kretzschmar,H,, Lewczuk,P., Lubec,G., Marcus,K., Martens,L., Bustamante,N.P., Park,Y.M., Pennington,S.R., Robben,J., Stuhler,K., Reidegeld,K.A., Riederer,P., Rossier,J., Sanchez,J.C., Schrader,M., Stephan,C., Tagle,D., Thiele,H., Wang,J., Wiltfang,J., Yoo,J.S., Zhang,C.G., Klose,J., and Meyer,H.E.
  
• (2006). Monozygotic twin model reveals novel embryo-induced transcriptome changes of bovine endometrium in the preattachment period. Biol Reprod 74, 253-264
  Klein, C., Bauersachs, S., Ulbrich, S. E., Einspanier, R., Meyer, H. H., Schmidt, S. E., Reichenbach, H. D., Vermehren, M., Sinowatz, F., Blum, H. und Wolf, E.
  
• (2006). Proteome research based on modern liquid chromatography - tandem mass spectrometry: separation, identification and quantification. Journal of Neural Transmission 113, 973-994
  Frohlich,T. and Arnold,G.J.
  
• (2006). Purification of His-tagged hybrid phage antibody. Anal Biochem 352, 154-156
  Donzeau, M., Bauersachs, S., Blum, H., Reichelt, P., Rohnisch, T. und Nagel, W.
  
• (2007). Dual specificities of the glyoxysomal/peroxisomal processing protease Deg15 in higher plants. Proc. Natl. Acad. Sci. U. S. A. 104, 11501-11506
  Helm,M., Luck,C, Prestele,J., Hierl,G., Huesgen,P.F., Frohlich,T., Arnold.G.J., Adamska,l., Gorg,A., Lottspeich,F., and Gietl,C.
  
• (2007). Single chain Fv antibodies directed against the 37kDa/67kDa laminin receptor as therapeutic tools in prion diseases. Mol. Immunol. 45, 144-151
  Zuber,C., Knackmuss,S., Rey,C., Reusch,U., Rottgen,P., Frohlich,T., Arnold,G.J., Pace,C., Mitteregger,G., Kretzschmar,H.A., Little,M., and Weiss.S.