Intraartikuläre Applikation von Opioiden und Corticotropin Releasing Factor (CRF) bei chronischer Arthritis

• Antragsteller: Professor Dr. Christoph Stein
• Fachliche Zuordnung: Anästhesiologie
• Förderung: Förderung von 2005 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5377227

• Erstellungsjahr: 2011

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2004) Characterization of mu opioid receptor binding and G protein coupling in rat hypothalamus, spinal cord, and primary afferent neurons during inflammatory pain. J Pharmacol Exp Ther 308:712-718
  Shaqura MA, Zöllner C, Mousa SA, Stein C, Schäfer M
  
• (2004) Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells. Pain 112:229-238
  Brack A, Rittner HL, Machelska H, Leder K, Mousa SA, Schäfer M, Stein C
  
• (2004) Endogenous peripheral antinociception in early inflammation is not limited by the number of opioidcontaining leukocytes but by opioid receptor expression. Pain 108:67-75
  Brack A, Rittner HL, Machelska H, Shaqura M, Mousa SA, Labuz D, Zöllner C, Schäfer M, Stein C
  
• (2004) Increased numbers of opioid expressing inflammatory cells do not affect intra-articular morphine analgesia. Br J Anaesth 93:375-380
  Likar R, Mousa SA, Philippitsch G, Steinkellner H, Koppert W, Stein C, Schäfer M
  
• (2004) Mobilization of opioidcontaining polymorphonuclear cells by hematopoietic growth factors and influence on inflammatory pain. Anesthesiology 100:149-157
  Brack A, Rittner HL, Machelska H, Beschmann K, Sitte N, Schäfer M, Stein C
  
• (2004) Rapid upregulation of mu opioid receptor mRNA in dorsal root ganglia in response to peripheral inflammation depends on neuronal conduction. Neuroscience 129:473-479
  Pühler W, Zollner C, Brack A, Shaqura MA, Krause H, Schäfer M, Stein C
  
• (2004) Selectins and integrins but not platelet-endothelial cell adhesion molecule-1 regulate opioid inhibition of inflammatory pain. Br J Pharmacol 142:772-780
  Machelska H, Brack A, Mousa SA, Schopohl JK, Rittner HL, Schäfer M, Stein C
  
• (2004) Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception. Anesthesiology 101:204-211
  Brack A, Labuz D, Schiltz A, Rittner HL, Machelska H, Schäfer M, Reszka R, Stein C
  
• (2006) Interleukin-1 beta contributes to the upregulation of kappa opioid receptor mRNA in dorsal root ganglia in response to peripheral inflammation. Neuroscience 141:989-998
  Pühler W, Rittner HL, Mousa SA, Brack A, Krause H, Stein C, Schäfer M
  
• (2006) Pain control by CXCR2 ligands through Ca2+-regulated release of opioid peptides from polymorphonuclear cells. FASEB J 20:2627-2629
  Rittner HL, Labuz D, Schaefer M, Mousa SA, Schulz S, Schäfer M, Stein C, Brack A
  
• (2007) Beta-endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis. Ann Rheum Dis 66:871-879
  Mousa SA, Straub RH, Schäfer M, Stein C
  
• (2007) Influence of pain treatment by epidural fentanyl and bupivacaine on homing of opioid-containing leukocytes to surgical wounds. Brain Behav Immun 21:544-552
  Heurich M, Mousa SA, Lenzner M, Morciniec P, Kopf A, Welte M, Stein C
  
• (2007) Involvement of intra-articular corticotropin-releasing hormone in postoperative pain modulation. Clin J Pain 23:136- 142
  Likar R, Mousa SA, Steinkellner H, Koppert W, Philippitsch G, Stein C, Schäfer M
  
• (2007) Lymphocytes upregulate signal sequence-encoding proopiomelanocortin mRNA and beta-endorphin during painful inflammation in vivo. J Neuroimmunol 183:133-145
  Sitte N, Busch M, Mousa SA, Labuz D, Rittner H, Gore C, Krause H, Stein C, Schäfer M
  
• (2007) Muopioid receptor activation modulates transient receptor potential vanilloid 1 (TRPV1) currents in sensory neurons in a model of inflammatory pain. Mol Pharmacol 71:12-18
  Endres-Becker J, Heppenstall PA, Mousa SA, Labuz D, Oksche A, Schäfer M, Stein C, Zöllner C
  
• (2008) Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. J Clin Invest 118:1065-1073
  Zöllner C, Mousa SA, Fischer O, Rittner HL, Shaqura M, Brack A, Shakibaei M, Binder W, Urban F, Stein C, Schäfer M
  
• (2009) Antinociception by neutrophil-derived opioid peptides in noninflamed tissue - role of hypertonicity and the perineurium. Brain Behav Immun 23(4):548-557
  Rittner HL, Hackel D, Yamdeu RS, Mousa SA, Stein C, Schäfer M, Brack A
  
• (2009) Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. PLoS Pathog 5:e1000362
  Rittner HL, Hackel D, Voigt P, Mousa S, Stolz A, Labuz D, Schäfer M, Schaefer M, Stein C, Brack A
  
• (2009) Peripheral non-viral MIDGE vector-driven delivery of betaendorphin in inflammatory pain. Mol Pain; 5:72
  Machelska H, Schroff M, Oswald D, Binder W, Sitte N, Mousa SA, Rittner HL, Brack A, Labuz D, Busch M, Wittig B, Schäfer M, Stein C
  
• (2010) Blockade of intra-articular adrenergic receptors increases analgesic demands for pain relief after knee surgery. Rheumatol Int.
  Kager I, Mousa SA, Sieper J, Stein C, Pipam W, Likar R