Intraartikuläre Applikation von Opioiden und Corticotropin Releasing Factor (CRF) bei chronischer Arthritis

• Applicant: Professor Dr. Christoph Stein
• Subject Area: Anaesthesiology
• Term: from 2005 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5377227

• Final Report Year: 2011

No abstract available

Publications

• (2004) Characterization of mu opioid receptor binding and G protein coupling in rat hypothalamus, spinal cord, and primary afferent neurons during inflammatory pain. J Pharmacol Exp Ther 308:712-718
  Shaqura, Mohammed A.; Zöllner, Christian; Mousa, Shaaban A.; Stein, Christoph & Schäfer, Michael
  
• (2004) Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells. Pain 112:229-238
  Brack, Alexander; Rittner, Heike L.; Machelska, Halina; Leder, Kerstin; Mousa, Shaaban A.; Schäfer, Michael & Stein, Christoph
  
• (2004) Endogenous peripheral antinociception in early inflammation is not limited by the number of opioidcontaining leukocytes but by opioid receptor expression. Pain 108:67-75
  Brack, Alexander; Rittner, Heike L; Machelska, Halina; Shaqura, Mohammed; Mousa, Shaaban A; Labuz, Dominika; Zöllner, Christian; Schäfer, Michael & Stein, Christoph
  
• (2004) Increased numbers of opioid expressing inflammatory cells do not affect intra-articular morphine analgesia. Br J Anaesth 93:375-380
  Likar, R.; Mousa, S.A.; Philippitsch, G.; Steinkellner, H.; Koppert, W.; Stein, C. & Schäfer, M.
  
• (2004) Mobilization of opioidcontaining polymorphonuclear cells by hematopoietic growth factors and influence on inflammatory pain. Anesthesiology 100:149-157
  Brack, Alexander; Rittner, Heike L.; Machelska, Halina; Beschmann, Karin; Sitte, Nicolle; Schäfer, Michael & Stein, Christoph
  
• (2004) Rapid upregulation of mu opioid receptor mRNA in dorsal root ganglia in response to peripheral inflammation depends on neuronal conduction. Neuroscience 129:473-479
  Puehler, W.; Zöllner, C.; Brack, A.; Shaqura, M.A.; Krause, H.; Schäfer, M. & Stein, C.
  
• (2004) Selectins and integrins but not platelet-endothelial cell adhesion molecule-1 regulate opioid inhibition of inflammatory pain. Br J Pharmacol 142:772-780
  Machelska, Halina; Brack, Alexander; Mousa, Shaaban A; Schopohl, Julia K; Rittner, Heike L; Schäfer, Michael & Stein, Christoph
  
• (2004) Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception. Anesthesiology 101:204-211
  Brack, Alexander; Labuz, Dominika; Schiltz, Anu; Rittner, Heike L.; Machelska, Halina; Schäfer, Michael; Reszka, Regina & Stein, Christoph
  
• (2006) Interleukin-1 beta contributes to the upregulation of kappa opioid receptor mRNA in dorsal root ganglia in response to peripheral inflammation. Neuroscience 141:989-998
  Puehler, W.; Rittner, H.L.; Mousa, S.A.; Brack, A.; Krause, H.; Stein, C. & Schäfer, M.
  
• (2006) Pain control by CXCR2 ligands through Ca2+-regulated release of opioid peptides from polymorphonuclear cells. FASEB J 20:2627-2629
  Rittner, Heike L.; Labuz, Dominika; Schaefer, Michael; Mousa, Shaaban A.; Schulz, Stefan; Schäfer, Michael; Stein, Christoph; Brack, Alexander; Rittner, Heike L.; Labuz, Dominika; Schaefer, Michael; Mousa, Shaaban A.; Schulz, Stefan; Schäfer, Michael; Stein, Christoph & Brack, Alexander
  
• (2007) Beta-endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis. Ann Rheum Dis 66:871-879
  Mousa, Shaaban A; Straub, Rainer H; Schäfer, Michael & Stein, Christoph
  
• (2007) Influence of pain treatment by epidural fentanyl and bupivacaine on homing of opioid-containing leukocytes to surgical wounds. Brain Behav Immun 21:544-552
  Heurich, Martin; Mousa, Shaaban A.; Lenzner, Moritz; Morciniec, Pawel; Kopf, Andreas; Welte, Martin & Stein, Christoph
  
• (2007) Involvement of intra-articular corticotropin-releasing hormone in postoperative pain modulation. Clin J Pain 23:136- 142
  Likar, Rudolf; Mousa, Shaaban A.; Steinkellner, Hermann; Koppert, Wolfgang; Philippitsch, Gudrun; Stein, Christoph & Schäfer, Michael
  
• (2007) Lymphocytes upregulate signal sequence-encoding proopiomelanocortin mRNA and beta-endorphin during painful inflammation in vivo. J Neuroimmunol 183:133-145
  Sitte, Nicolle; Busch, Melanie; Mousa, Shaaban A.; Labuz, Dominika; Rittner, Heike; Gore, Carmen; Krause, Hans; Stein, Christoph & Schäfer, Michael
  
• (2007) Muopioid receptor activation modulates transient receptor potential vanilloid 1 (TRPV1) currents in sensory neurons in a model of inflammatory pain. Mol Pharmacol 71:12-18
  Endres-Becker, Jeannette; Heppenstall, Paul A.; Mousa, Shaaban A.; Labuz, Dominika; Oksche, Alexander; Schäfer, Michael; Stein, Christoph & Zöllner, Christian
  
• (2008) Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. J Clin Invest 118:1065-1073
  Zöllner, Christian; Mousa, Shaaban A.; Fischer, Oliver; Rittner, Heike L.; Shaqura, Mohammed; Brack, Alexander; Shakibaei, Mehdi; Binder, Waltraud; Urban, Florian; Stein, Christoph & Schäfer, Michael
  
• (2009) Antinociception by neutrophil-derived opioid peptides in noninflamed tissue - role of hypertonicity and the perineurium. Brain Behav Immun 23(4):548-557
  Rittner, H.L.; Hackel, D.; Yamdeu, R.-S.; Mousa, S.A.; Stein, C.; Schäfer, M. & Brack, A.
  
• (2009) Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. PLoS Pathog 5:e1000362
  Rittner, Heike L.; Hackel, Dagmar; Voigt, Philipp; Mousa, Shaaban; Stolz, Andrea; Labuz, Dominika; Schäfer, Michael; Schaefer, Michael; Stein, Christoph & Brack, Alexander
  
• (2009) Peripheral non-viral MIDGE vector-driven delivery of betaendorphin in inflammatory pain. Mol Pain; 5:72
  Machelska H, Schroff M, Oswald D, Binder W, Sitte N, Mousa SA, Rittner HL, Brack A, Labuz D, Busch M, Wittig B, Schäfer M, Stein C
  
• (2010) Blockade of intra-articular adrenergic receptors increases analgesic demands for pain relief after knee surgery. Rheumatol Int.
  Kager, Ingo; Mousa, Shaaban A.; Sieper, Joachim; Stein, Christoph; Pipam, W. & Likar, Rudolf