Learning-related gene expression in cortical systems: the impact of vascular and parenchymal amyloid
Final Report Abstract
The aim of the present set of studies was to elucidate the relative impact of different Alzheimer-disease related pathologies on cognitive function. Through use of a novel combination of behavioral and visualization techniques, we were able to demonstrate that both vascular and parencymal amyloid have independent effects on learning-related gene expression, and that these deficits are region-specific. Furthermore, the ability of individual cells to induce this gene was impaired by the local presence of amyloid and/or by the presence of intracellular amyloid-beta granules. These results should help guide therapeutic interventions as all pathological subtypes of amyloid must be taken into account. The tools and techniques developed for this and other related studies should be broadly useful for the research community.
Publications
- Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J Neurosci. 2008 Apr 16;28(16):4283-92
Bolmont T, Haiss F, Eicke D, Radde R, Mathis CA, Klunk WE, Kohsaka S, Jucker M, Calhoun ME
- Independent effects of intra- and extracellular Abeta on learning-related gene expression. Am J Pathol. 2009 Jul;175(1):271-82
Wegenast-Braun BM, Fulgencio Maisch A, Eicke D, Radde R, Herzig MC, Staufenbiel M, Jucker M, Calhoun ME
