Anwendung von in vivo Mikropunktionsuntersuchungen an der Niere der Adenosin A1 Rezeptor knockout Maus

• Antragsteller: Dr. Timo Rieg
• Fachliche Zuordnung: Pharmakologie
• Förderung: Förderung von 2005 bis 2008
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5450428

• Erstellungsjahr: 2008

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem. 2006 Feb;281(8):5072-83
  Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaier G, Nigam SK
  
• Stimulation of serum- and glucocorticoid-regulated kinase-1 gene expression by endothelin-1. Biochem Pharmacol. 2006 Apr;71(8}:1175-83
  Wolf SC, Schultze M, Risler T, Rieg T, Lang F, Schulze-Osthoff K, Brehm BR
  
• Adenosine AT receptors determine effects of caffeine on total fluid intake but not caffeine appetite. Eur J Pharmacol. 2007 Jan;555(2-3):174-7
  Rieg T, Schnermann J, Vallon V
  
• Aldosteroneinduced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha. J Clin Invest. 2007 Mar;117(3):773-83
  Zhang W, Xia X, Reisenauer MR, Rieg T, Lang F, Kuhl D, Vallon V, Kone BC
  
• Combined effects of carbonic anhydrase inhibitor and adenosine AI receptor antagonist on hemodynamic and tubular function in the kidney. Kidney Blood Press Res. 2007;30(6):388-99
  Miracle CM, Rieg T, Blantz RC, Vallon V, Thomson SC
  
• Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J. 2007 Nov;21(13):3717-26
  Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V
  
• The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion. Kidney Int. 2007 Sep;72(5):566-73
  Rieg T, Vallon V, Sausbier M, Sausbier U, Kaissling B, Ruth P, Osswald H
  
• Only partial loss of urate reabsorption in null mice for RST, the murine ortholog of the human urate transporter, URAT1. Physiol Genomics. 2008 Apr;33:180-92
  Eraly SA, Vallon V, Rieg T, Ahn SY, Wu W, Eraly SA, Nigam SK
  
• Organic Anion Transporter 3 Contributes to the Regulation of Blood Pressure. J Am Soc Nephrol. 2008 May 28. [Epub ahead of print]
  Vallon V, Eraly SA, Wikoff WR, Rieg T, Kaier G, Truong DM, Ahn SY, Mahapatra NR, Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, Nigam SK
  
• Ornithine decarboxylase inhibitor eliminates hyper-responsiveness of the early diabetic proximal tubule to dietary salt. Am J Physiol Renal Physiol. 2008 Jun 18. [Epub ahead of print]
  Miracle CM, Rieg T, Mansoury HA, Vallon V, Thomson SC
  
• Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol. Physiol Genomics. 2008 Apr; 294:F867-73
  Vallon V, Rieg T, Gangoiti JA, Wu W, Barshop BA, Wikoff WR, Nigam SK
  
• Vasopressin regulation of inner medullary collecting ducts and compensatory changes in mice lacking adenosine A, receptors. Am J Physiol Renal Physiol. 2008 Mar;294(3):F638-44
  Rieg T, Pothula K, Schroth J, Satriano J, Osswald H, Schnermann J, Insel PA, Bundey RA, Vallon V