Clearance of defective mRNA by-products by the ribosome-associated quality control pathway in stress and disease (B01)

• Subject Area: Biochemistry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 520471345

Translation of certain defective mRNAs can cause abnormally long pauses in ribosome elongation, resulting in truncated proteins that are likely to be dysfunctional. The ribosome associated quality control (RQC) pathway addresses these ribosome-stalled proteins for degradation, limiting their toxic effects. In the project we will systematically characterize defective transcripts arising upon proteotoxic stress at the ER, as well as the impact of RQC on proteome fidelity. By integrating transcriptomic and proteomic data, we envision obtaining a mechanistic understanding of the physiological causes and consequences of RQC.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1678: Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
• Applicant Institution: Universität zu Köln
• Project Head: Débora Broch Trentini Schmidt, Ph.D.