Investigating brain network interactions across behavioral domains to guide therapeutic stimulation for gait (B07*)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

Recent research highlights the intricate interactions between cognitive, limbic, and motor brain networks that are critical for complex tasks such as walking. Despite the effectiveness of deep brain stimulation (DBS) in improving motor symptoms in Parkinson's disease (PD), restoring differentiated motor skills, notably gait, remains a challenge. Normative connectomics studies in large patient cohorts will be used to uncover overlapping networks in ischemic stroke patients and in PD patients undergoing DBS to decipher potential cross-domain interactions between brain networks. The modulation of these cross-domain interactions will be investigated in a pilot interventional DBS study to pave the way for a more personalized treatment approach.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Matthias Endres; Dr. Anna Kufner; Dr. Martin Reich