Mutation-Sensitive Prediction of Transcription Factor-DNA Interactions in Plants (A03)

• Subject Area: Plant Genetics and Genomics ; Bioinformatics and Theoretical Biology ; Evolution and Systematics of Plants and Fungi ; Structural Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514901783

This bioinformatic project analyses the interaction between transcription factor (TF) proteoforms and their cis-regulatory target promoters. Integrating DNA-level pattern identification and 3-D structural modelling, it explores the dual impact of genomic diversity on TF function, focusing on structural differences within DNA-binding domains and non-coding genetic variation in promoters. Investigating the simultaneous influence of nsSNPs in TFs and non-coding promoter SNPs aims to understand the co-evolution of TFs and their binding sites. High-confidence predictions may guide future projects in subsequent funding periods.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1664: Plant Proteoform Diversity - SNP2Prot
• Applicant Institution: Martin-Luther-Universität Halle-Wittenberg
• Project Heads: Professor Dr. Ivo Große; Professor Dr. Jens Meiler