Development of SNPstar 2.0 and computational prediction of putative proteoform candidates with high functional proteoform variation (D02)

• Subject Area: Plant Genetics and Genomics ; Bioinformatics and Theoretical Biology ; Evolution and Systematics of Plants and Fungi
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514901783

D02 focuses on genomics, aiming to develop SNPstar 2.0 and predict proteoform candidates with high functional variation based on genomic data. SNPstar 2.0, enhanced with structural models from D01, will feature displays of nsSNP-affected residues and expand to other plant species. The project will introduce a quantitative score for SNP effects on proteoform structure and function. This score aids wet-lab scientists in selecting high-scoring variants for experimental analysis in the second funding period, bridging the gap between genomic information and functional consequences of SNPs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1664: Plant Proteoform Diversity - SNP2Prot
• Applicant Institution: Martin-Luther-Universität Halle-Wittenberg
• Project Heads: Professor Dr. Ivo Große; Professor Dr. Marcel Quint