Redox signalling by the cellular prion protein (PrPC) and its role in the cellular calcium homeostasis

Antragsteller Professor Dr. Jochen W. Herms

Fachliche Zuordnung Molekulare Biologie und Physiologie von Nerven- und Gliazellen

Förderung Förderung von 2005 bis 2009

Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5455719

Erstellungsjahr 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Activation of phosphatidylinositol 3'kinase by copper bound prion protein and its rote in cell survival. Biochem Biophys Res Commun. 332:75-82, 2005
Vassallo N., Herms J., Behrens C., Krebs B., Windl O., Kretzschmar H.
Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons. J Neurochem. 98(6):1876-85, 2006
Fuhrmann, M., Bittner T. Mitteregger, G., Moosmang S., Kretzschmar H., Herms J.
Prion protein induced signaling cascades in monocytes. Biochem Biophys Res Commun. 340:13-22., 2006
Krebs B, Dorner-Ciossek C, Schmalzbauer R, Vassallo N, Herms J, Kretzschmar HA
The cellular prion protein modulates the intracellular calcium response to hydrogen peroxide. J Neurochem. 100:358-67, 2007
Krebs, B., Wiebelitz, A., Balitzki-Korte, B., Vassallo, N., Paluch, S., OnoderaT., Kretzschmar. H., Herms, J.
The role of the octarepeat region in neuroprotective function of the cellular prion protein. Brain Pathol. 17:174-83, 2007
Mitteregger G, Vosko M, Krebs B, Xiang W, Kohlmannsperger V, Nölting S, Hamann GF, Kretzschmar HA
Evidence for an association of prion protein and sphingolipid-mediated signaling. J Neurochem. 106:1459-70, 2008
Schmalzbauer R, Eigenbrod S, Winoto-Morbach S, Xiang W, Schütze S, Bertsch U, Kretzschmar HA
The brain proteome profile is highly conserved between Prnp-/- and Prnp+/+ mice. Neuroreport 19:1027-31, 2008
Crecelius AC, Helmstetter D, Strangmann J, Mitteregger G, Fröhlich T, Arnold GJ, Kretzschmar HA