Redox signalling by the cellular prion protein (PrPC) and its role in the cellular calcium homeostasis

Applicant Professor Dr. Jochen W. Herms

Subject Area Molecular Biology and Physiology of Neurons and Glial Cells

Term from 2005 to 2009

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 5455719

Final Report Year 2009

Final Report Abstract

No abstract available

Activation of phosphatidylinositol 3'kinase by copper bound prion protein and its rote in cell survival. Biochem Biophys Res Commun. 332:75-82, 2005
Vassallo N., Herms J., Behrens C., Krebs B., Windl O., Kretzschmar H.
Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons. J Neurochem. 98(6):1876-85, 2006
Fuhrmann, M., Bittner T. Mitteregger, G., Moosmang S., Kretzschmar H., Herms J.
Prion protein induced signaling cascades in monocytes. Biochem Biophys Res Commun. 340:13-22., 2006
Krebs B, Dorner-Ciossek C, Schmalzbauer R, Vassallo N, Herms J, Kretzschmar HA
The cellular prion protein modulates the intracellular calcium response to hydrogen peroxide. J Neurochem. 100:358-67, 2007
Krebs, B., Wiebelitz, A., Balitzki-Korte, B., Vassallo, N., Paluch, S., OnoderaT., Kretzschmar. H., Herms, J.
The role of the octarepeat region in neuroprotective function of the cellular prion protein. Brain Pathol. 17:174-83, 2007
Mitteregger G, Vosko M, Krebs B, Xiang W, Kohlmannsperger V, Nölting S, Hamann GF, Kretzschmar HA
Evidence for an association of prion protein and sphingolipid-mediated signaling. J Neurochem. 106:1459-70, 2008
Schmalzbauer R, Eigenbrod S, Winoto-Morbach S, Xiang W, Schütze S, Bertsch U, Kretzschmar HA
The brain proteome profile is highly conserved between Prnp-/- and Prnp+/+ mice. Neuroreport 19:1027-31, 2008
Crecelius AC, Helmstetter D, Strangmann J, Mitteregger G, Fröhlich T, Arnold GJ, Kretzschmar HA