Structure and functional analysis of Rax1p and Rax2p

• Antragstellerin: Dr. Naimeh Taheri Talesh
• Fachliche Zuordnung: Entwicklungsbiologie
• Förderung: Förderung von 2005 bis 2008
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5456427

The cell polarization is a central feature of cellular morphogenesis, which involves the asymmetric organization of the cytoskeleton and polarized secretion along an appropriate axis. In the budding yeast Saccharomyces cerevisiae, there are two distinct patterns of polarization-axis selection and oriented cell division depending on their cell type. These patterns are dependent on distinct types of marker proteins in the cell cortex. The bipolar budding of diploid cells depends on persistent landmarks at the distal and proximal poles that involve the proteins Bud8p and Bud9p. Two integral membrane proteins, Rax1p and Rax2p, also appear to function specifically in bipolar budding. Both proteins are localized at the distal and proximal poles of yeast cells and interact with both membrane proteins Bud8p and Bud9p. In this work, we aim to characterize Rax1p and Rax2p and to identify proteins interacting with Rax1p and Rax2p that are crucial for establishment and/or maintenance of bipolar budding pattern in yeast.

• DFG-Verfahren: Forschungsstipendien
• Internationaler Bezug: USA
• Gastgeberin: Professorin Dr. Hay-Oak Park