The role of RNF213 and its variants in lung tumor (A08)

• Subject Area: Cell Biology ; Bioinformatics and Theoretical Biology ; Hematology, Oncology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514894665

Ring finger protein 213 (RNF213) contains an active E3 ligase domain and plays a role in modulating cell-intrinsic inflammation and vascularization. RNF213 is expressed in different splicing isoforms whose abundance and localization vary across the lung cancer microenvironment, and these variations are associated with overall patient survival. In the proposed project, our aim is to define the ubiquitylation substrates and molecular and cellular functions of RNF213 and its variants. Focusing on the role of RNF213 variants in lung cancer, we aim to identify novel RNF213-dependent cancer vulnerabilities that may be targeted to modulate lung cancer progression.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 387: Functionalizing the Ubiquitin System against Cancer - UbiQancer
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Dr. Katharina Imkeller; Professor Dr. Christian Münch