Analyzing and targeting non-catalytic functions of Aurora-A in AML (B07)

• Subject Area: Biochemistry ; Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514894665

In B07, Elmar Wolf and Gabriele Büchel will target the Aurora-A complexes and their oncogenic function in AML by PROTACs. First, they will investigate which non-substrate proteins directly bind Aurora-A in AML, the structural nature of these interactions, and the effects of PROTAC-induced depletion of Aurora-A on these protein complexes. Using auxin models (ubiquitin-based DEGRON systems), they will analyze the phenotype of Aurora-A interaction partner degradation. Second, they will test the therapeutic potential of Aurora-A degradation in AML mouse models. In addition, they aim to identify biomarkers for the use of Aurora-A PROTACs in AML patients.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 387: Functionalizing the Ubiquitin System against Cancer - UbiQancer
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professorin Dr. Gabriele Büchel; Professor Dr. Elmar Wolf