Brain mechanisms differentiating aggressive vs. non-aggressive psychopathology as sequelae of early life maltreatment (C06)

• Subject Area: Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 512007073

C06 identifies specific neuronal mechanisms related to the NVS and CS in female and male clinical samples with a history of early-life maltreatment (ELM) who exhibit externalizing, aggressive psychopathologies as opposed to internalizing psychopathology. The project will explore the interaction of the NVS and CS as well as the modulating effects of theory-of-mind (ToM) on the NVS and CS using a series of fMRI and behavioral tasks. Furthermore, we will investigate the role of hormonal stress responses and will use EMA to assess anger and aggression in everyday life.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 379: Neuropsychobiology of Aggression: A Transdiagnostic Approach in Mental Disorders
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professorin Dr. Sabine C. Herpertz; Dr. Corinne Neukel