FOR 426:  Complex RNA-protein interactions in the maturation and function of eukaryotic mRNA

• Subject Area: Biology
• Term: from 2001 to 2006
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5468076

No abstract available

• DFG Programme: Research Units

Projects

• 3`-Processing of mRNA: Composition and dynamics of the processing complex and reconstitution of selected factors (Applicant Wahle, Elmar )
• Characterization of the endo/exonuclease Tb08 as a core component of the RNA editing RNP in African trypanosomes (Applicant Göringer, H. Ulrich )
• Complex RNA-protein interactions in the maturation and functions of eukaryotic mRNA (Applicant Wahle, Elmar )
• Crystallographic studies on snRNP-and SMN-Associated DExD/H-box proteins and on the editosome-specific nuclease TbMP42 (Applicant Ficner, Ralf )
• Dynamic organisation of the localised ASH1 messenger ribonucleoprotein complex in yeast. (Applicant Jansen, Ralf-Peter )
• Higher order structure and remodelling of the spliceosomal RNA network (Applicant Lührmann, Reinhard )
• Molecular dissection of the assembly pathway of spliceosomal U snRNPs (Applicant Fischer, Utz )
• Molecular mechanisms of hereditary thrombophilia: physiological function of prothrombin mRNA 3` end maturation (Applicant Kulozik, Ph.D., Andreas Eckhard )
• Purification of RNP complexes involved in RNA nuclear export (Applicant Mattaj, Iain W. )
• Regulation of mammalian mRNA splicing by CA repeat enhancer elements (Applicant Bindereif, Albrecht )
• The role of the poly(A)-specific ribonuclease (PARN) in mRNA decay (Applicant Wahle, Elmar )
• The translationally regulated msl-2 mRNP from Drosophila (Applicant Hentze, Matthias )

• Spokesperson: Professor Dr. Elmar Wahle