SPP 1045: Struktur, Funktion und Regulation des 20S/26S Ubiquitin-Proteasomsystems
Subject Area
Biology
Term
from 1998 to 2004
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5468424
Project Description
No abstract available
DFG Programme
Priority Programmes
Projects
Adressierung von 26S Proteasomen an das Membrannetzwerk bestehend aus Kernhüllen und rauhem ER in Hefe (Targeting mechanism of yeast 26S proteasomes to the NE/ER membrane network)
(Applicant
Enenkel, Cordula
)
Biochemical and functional analysis of multicatalytic proteinase subtypes in 20S and 26S proteasoms
(Applicant
Dahlmann, Burkhardt
)
Biogenese des Proteasoms in Saccharomyces cerevisiae
(Applicant
Dohmen, Jürgen
)
Charakterisierung einer potentiellen Entfaltungsaktivität von 26S Protease Untereinheiten, die zur Familie der AAA Proteine gehören
(Applicant
Schmidt, Marion
)
Defining a regulatory system at the interface of protein folding and protein degradation
(Applicant
Höhfeld, Jörg
)
Die molekulare Architektur eukaryotischer und prokaryotischer regulatorischer Komplexe des Proteasoms (The molecular architecture of eukaryotic and prokaryotic regulatory complexes of the proteasome)
(Applicant
Baumeister, Wolfgang
)
Die Rolle des COP9 Signalosoms bei der Regulation der Ubiquitin- und Proteasom-abhängigen Proteolyse von p53, c-Jun und p27 (The role of the COP9 signalosome in the regulation of the ubiquitin- and proteasome-dependent proteolysis of p53,c-Jun and p27)
(Applicant
Dubiel, Wolfgang
)
Erkennung proteolytischer Substrate durch Cdc20 und Hct1, Rezeptoren der Ubiquitin-Ligase APC (Recognition of proteolytic substrates by Cdc20 and Hct1, receptors of the ubiquitin-ligase APC)
(Applicant
Seufert, Wolfgang
)
Funktionelle Analyse der Proteasomregulatoren PI31, PA28y/Ki und warum PA28aß die Generierung von MHC Klasse I Epitopen unterstützt Functional analysis of proteasome regulators PI31, PA28y/Ki and why the PA28aß supports the generation of MHC class I antigens
(Applicant
Kloetzel, Peter Michael
)
Genetische Analyse des Mechanismus der ubiquitinilierungsabhängigen Kontrolle der Signaltransduktion durch den T-Zell Rezeptor (The genetic analysis of the mechanism of the ubiquitination-dependent control of T cell receptor signalling)
(Applicant
Tarakhovsky, Alexander
)
Identification and characterization of target proteins of the ubiquitin-protein ligase E6-AP (Identifizierung von Zielproteinen der putativen Ubiquitin-Proteinligase E6-AP)
(Applicant
Scheffner, Martin
)
Implications of ß-subunit exchanges and of interactions with the activator PA28 for the cleavage preferences of the 20S proteasome: A quantitative analysis based on kinetic experiments
(Applicant
Holzhütter, Hermann-Georg
)
Mechanismus der ER-abhängigen Degradation von Proteinen des murinen Cytomegalovirus
(Applicant
Koszinowski, Ulrich H.
)
Mutationsanalyse der Proteasomenfunktion (Mutational analysis of proteasome function)
(Applicant
Heinemeyer, Wolfgang
)
Regulation, dislocation and elimination of membrane proteins of different eukaryotic organelles: Function of the proteasome and its helpers (Regulation, Dislokation und Eliminierung von Membranproteinen verschiedener eukaryonter Organellen: Die Funktion des proteasoms und seiner Helfer)
(Applicant
Wolf, Dieter H.
)
Regulation of the ubiquitin-proteasome-system during oxidative stress
(Applicant
Grune, Tilman
)
Spezifität und Mechanismus des eukaryotischen 20S/26S Proteasoms (Specificity and mechanism of the eukaryotic 20S/26S proteasome)
(Applicant
Schild, Hansjörg
)
Structur and function of mutants of the 20S proteasome from S. cerevisiae (Struktur und Funktion von Mutanten des 20S Proteasoms aus S. cerevisiae)
(Applicant
Huber, Robert
)
The kinetochore protein Slk19 interacts with the proteasome: Function of the Slk19-proteasome complex in control of meiosis and mitosis
(Applicant
Hilt, Wolfgang
)
The role of the proteasome in the development of atherosclerotic lesions: possible application of proteasome inhibitors in the therapy of atherosclerosis
(Applicant
Stangl, Karl
)
The role of ubiquitination in the transport and turnover of membrane proteins
(Applicant
Kölling, Ralf
)
Ubiquitin abhängige Proteolyse eines Substrates des Zellkerns (Ubiquitin dependent proteolysis of a nuclear substrate)
(Applicant
Sommer, Thomas
)
Ubiquitin-Konjugat Bildung und Interaktion mit dem Proteasom (Ubiquitin Conjugate Formation and Proteasome Targeting)
(Applicant
Jentsch, Stefan
)
Untersuchungen zur Rolle der Tripeptidylpeptidase II-vermittelten Proteolyse invivo (In vivo-Role of Tripeptidyl Peptidase II-Mediated Proteolysis in Murine Cells and Mice)
(Applicant
Niedermann, Gabriele
)
Spokesperson
Professor Dr. Peter Michael Kloetzel
