SPP 1071:  Radikale in der enzymatischen Katalyse

• Subject Area: Biology ; Medicine
• Term: from 1999 to 2004
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5469433

No abstract available

• DFG Programme: Priority Programmes
• International Connection: United Kingdom

Projects

• Biophysical Investigations on the Coupled Electron/Proton-Transfer in recombinant Ribonucleotide Reductase from Mouse Englisch: (Applicant Schmidt, Peter Paul )
• C-H bond activation in Ribonucleotide reductases (Applicant Zipse, Hendrik )
• Characterization of radicals in anaerobic degradation of benzoate, acytelene, and glycol ethers (Applicant Schink, Bernhard )
• Coordinatorfund of the Priority Programme "Radicals in Enzymatic Catalysis" (Applicant Buckel, Wolfgang )
• Development of mechanistic probes for the detection of radical and radical ionic intermediates in enzymatic reactions (Applicant Schmittel, Michael )
• Die Rolle des Thiolatliganden in Hämproteinen (Applicant Ullrich, Volker )
• Exploiting Nuclear Spin Polarization to Investigate Enzyme-Mediated Free Radical Reactions via in situ NMR (Applicant Bargon, Joachim )
• Functional important radical-containing intermediates in thiolate-coordinated heme proteins: cytochrome P450 and chloroperoxidase (Applicant Trautwein, Alfred X. )
• Functional important radical-containing intermediates in thiolate-coordinated heme proteins: cytochrome P450 and chloroperoxidase (Applicant Jung, Christiane )
• High-Field Electron Paramagnetic Resonance (EPR) and Double Resonance Methods for Mechanistic Studies of Ribonucleotide Reductase and Heterodisulfide Reductase (Applicant Bennati, Marina )
• Homogeneous catalysis of aerobic oxidation of alcohols and amines: Biomimetic metal-phenoxyl radical reactivity (Applicant Chaudhuri, Phalguni )
• Models for Galactose Oxidase (GOase) Based on Combinatorial Peptoid Libraries (Applicant Berkessel, Albrecht )
• Possible radical mechanism in enzymatic carboxylation of phenol (Applicant Fuchs, Georg )
• Radical enzymes for the biosynthesis of tetrapyrroles (Applicant Jahn, Dieter )
• Radical reactions in fermentation pathways of nitrogenous compounds (Applicant Buckel, Wolfgang )
• Radicals in anaerobic aromatic metabolism (Applicant Boll, Matthias )
• Radicals in decarboxylation of 2-arylacetates? The formations of Toluene from Phenylacetate, p-Cresol from p-Hydroxiphenylacetate and Skatole from Indoleacetate (Applicant Selmer, Thorsten )
• Reaction mechanism and activation reaction of benzylsuccinate synthase, a novel glycyl-radical-enzyme (Applicant Heider, Johann )
• Röntgenstrukturanalyse der Pyruvat-Formiatlyase (PFL) (Applicant Kabsch, Wolfgang )
• Spectroscopic analysis of functionally essential radicals of the radical enzyme Ribonucleotide Reductase (RNR) (Applicant Lendzian, Friedhelm )
• Structure and catalytic mechanism of heterodisulfide reductase from methanogenic archaea (Applicant Hedderich, Reiner )
• The role and sources of the 5`deoxyadenosyl radical (Applicant Rétey, János )
• Theoretische Untersuchungen an biomimetischen Modellen der Galactose Oxidase (Applicant Hohlneicher, Georg )
• Untersuchungen zu einkernigen Kupfer- und Eisenkomplexen mit biomimetischer Relevanz zur Reaktionsweise von Radikalen in biologischen Prozessen (Applicant Krüger, Ph.D., Hans-Jörg )
• Untersuchungen zum Reaktionsmechanismus einer pflanzlichen Oxidase, von Monooxygenasen und von Modellverbindungen für Dioxygenasen (Applicant Krebs, Bernt )
• X-ray structure analyses of 4-hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum and possible complexes with substrate, product as well as substrate and product analogues (Applicant Messerschmidt, Albrecht )

• Spokesperson: Professor Dr. Wolfgang Buckel