SPP 1071:  Radikale in der enzymatischen Katalyse

• Fachliche Zuordnung: Biologie ; Medizin
• Förderung: Förderung von 1999 bis 2004
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5469433

Keine Zusammenfassung vorhanden

• DFG-Verfahren: Schwerpunktprogramme
• Internationaler Bezug: Großbritannien

Projekte

• Biophysikalische Untersuchungen des gekoppelten Elektronen/Protronen-Transfers in der rekombinanten Ribonukleotid-Reduktphase der Maus (Antragsteller Schmidt, Peter Paul )
• C-H-bond activation in ribonucleotide reductases: a theoretical study (Antragsteller Zipse, Hendrik )
• Characterisation of p-hydroxyphenylacetate decarboxylase from Clostridium difficile, a novel glycyl radical enzyme forming p-cresol (Antragsteller Selmer, Thorsten )
• Characterisation of radicals involved in anaerobic degradation of glycol ethers, trihydroxybenzene and acetylene (Antragsteller Schink, Bernhard )
• Development of mechanistic probes for the detection of radical and radical ionic intermediates in enzymatic reactions (Antragsteller Schmittel, Michael )
• Die Rolle des Thiolatliganden in Hämproteinen (Antragsteller Ullrich, Volker )
• Exploiting Nuclear Spin Polarization to Investigate Enzyme-Mediated Free Radical Reactions via in situ NMR (Antragsteller Bargon, Joachim )
• Functional important radical-containing intermediates in thiolate-coordinated heme proteins: cytochrome P450 and chloroperoxidase (Antragsteller Trautwein, Alfred X. )
• Functional important radical-containing intermediates in thiolate-coordinated heme proteins: cytochrome P450 and chloroperoxidase (Antragstellerin Jung, Christiane )
• High-Field Electron Paramagnetic Resonance (EPR) and Double Resonance Methods for Mechanistic Studies of Ribonucleotide Reductase and Heterodisulfide Reductase (Antragstellerin Bennati, Marina )
• Homogeneous catalysis of aerobic oxidation of alcohols and amines: Biomimetic metal-phenoxyl radical reactivity (Antragsteller Chaudhuri, Phalguni )
• Identification and characterisation of transient free and iron-coupled radicals in ribonucleotide reductase (RNR) by ENDOR and High-Field EPR spectroscopy (Antragsteller Lendzian, Friedhelm )
• Models for Galactose Oxidase (GOase) Based on Combinatorial Peptoid Libraries (Antragsteller Berkessel, Albrecht )
• Possible radical mechanism in enzymatic carboxylation of phenol (Antragsteller Fuchs, Georg )
• Radical enzymes for the biosynthesis of tetrapyrroles (Antragsteller Jahn, Dieter )
• Radical reactions in fermentation pathways of nitrogenous compounds (Antragsteller Buckel, Wolfgang )
• Radikale in der enzymatischen Katalyse (Antragsteller Buckel, Wolfgang )
• Reaction mechanism and activation reaction of benzylsuccinate synthase, a novel glycyl-radical-enzyme (Antragsteller Heider, Johann )
• Role of radicals in enzymatic reduction of the aromatic ring (Antragsteller Boll, Matthias )
• Röntgenstrukturanalyse der Pyruvat-Formiatlyase (PFL) (Antragsteller Kabsch, Wolfgang )
• Structure and catalytic mechanism of heterodisulfide reductase from methanogenic archaea (Antragsteller Hedderich, Reiner )
• The role and sources of the 5`-deoxyadenosyl radical (Antragsteller Rétey, János )
• Theoretische Untersuchungen an biomimetischen Modellen der Galactose Oxidase (Antragsteller Hohlneicher, Georg )
• Untersuchungen zu einkernigen Kupfer- und Eisenkomplexen mit biomimetischer Relevanz zur Reaktionsweise von Radikalen in biologischen Prozessen (Antragsteller Krüger, Ph.D., Hans-Jörg )
• Untersuchungen zum Reaktionsmechanismus einer pflanzlichen Oxidase, von Monooxygenasen und von Modellverbindungen für Dioxygenasen (Antragsteller Krebs, Bernt )
• X-ray structure analyses of 4-hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum and possible complexes with substrate, product as well as substrate and product analogues (Antragsteller Messerschmidt, Albrecht )

• Sprecher: Professor Dr. Wolfgang Buckel