The renal capsule as a critical barrier interface in congestive nephropathy

• Applicant: Privatdozent Dr. Konrad-Robert Buscher
• Subject Area: Nephrology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 547722671

Congestive Nephropathy refers to kidney injury caused by venous congestion. Our hypothesis posits that the renal capsule is not merely a passive fibrous layer that protects the organ, but rather a complex barrier tissue that plays a significant role in congestion-related kidney disease. Our data suggest that the capsule comprises a complex cellular landscape that specifically adapts during and after injury with a potential role in lymphatic dysfunction and fibrosis. These adaptations could increase the capsular stiffness as a key mechanism of congestive nephropathy. Thus, this project aims to investigate the capsular microenvironment of the kidney in mice and humans, and clarify its role as a barrier interface between perirenal and cortical tissues. Our goal is to comprehend the mechanical properties as well as the renal and perirenal routes of leukocyte trafficking, and how they impact the extracellular matrix, lymph flow, microcirculation and kidney function. By unraveling these findings, we anticipate gaining new insights into congestive nephropathy and the cardiorenal syndrome.

• DFG Programme: Research Grants