Unlocking Cardiometabolic Health: Investigating Very-Long-Chain Saturated Fatty Acids via Lipidomics Biomarkers and Their Dietary, Lifestyle, and Genetic Influences

• Applicant: Professor Dr. Matthias Bernd Schulze
• Subject Area: Nutritional Sciences
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 548364193

Although reducing saturated fatty acid intake has been a cornerstone of dietary guidance, there is an ongoing debate regarding the diverse roles of saturated fatty acids with differing chain lengths. Very long-chain saturated fatty acids (VLCSFAs) represent a unique subgroup, with higher circulating levels being discussed in relation to reduced risks of cardiometabolic diseases. However, it is unclear whether these associations are consistent across different lipid fractions, particularly considering intercorrelations with other fatty acids that have not been accounted for in previous studies. To investigate VLCSFA levels in a broad range of different lipid classes and their associations with type 2 diabetes and cardiovascular disease, we will use a large-scale longitudinal cohort study, EPIC-Potsdam. In addition, although nuts are a significant dietary source of VLCSFA, other lifestyle-related and genetic factors also seem to affect circulating levels. To clarify the direct effect of peanuts on VLCSFA concentrations in different lipid fractions, we will make use of plasma samples of a controlled intervention trial called ARISTOTLE. Investigating additional food sources, alcohol consumption, activity patterns, and genetics in EPIC-Potsdam will enhance our understanding of the relationship between lifestyle factors and genetic influences on VLCSFA concentrations.

• DFG Programme: Research Grants
• International Connection: Spain
• Cooperation Partner: Professorin Rosa María Lamuela-Raventós