Project Details
Projekt
Antigen-independent mechanisms determining tissue damage in liver autoimmunity (A02)
Subject Area
Gastroenterology
Immunology
Immunology
Term
since 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 530990199
The liver has unique functions for immune tolerance but can also become a target of autoimmunity that causes liver damage, which we will explore by studying two recently recognised pathways mediating tissue damage. We will determine the contribution of autoaggressive (aa) CD8+ T cells to the development of autoimmune liver disease. Second, we will characterise the relevance of a lowered threshold to the induction of apoptosis in hepatocytes with loss of mitochondrial resistance for auto-immune liver disease. In this way, the project aims to develop novel targeted immune intervention strategies that selectively abrogate tissue-destructive autoaggression while sparing pathogen-specific immunity
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Dr. Michael Dudek; Professor Dr. Percy Alexander Knolle
