Project Details
Projekt
The role of short expressed peptides and cell type composition in autoimmune liver inflamma-tion (A06)
Subject Area
Gastroenterology
Term
since 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 530990199
To gain new insights into the pathogenesis of autoimmune liver diseases, we will study human hepatic translational events by measuring genome-wide active translation with ribosome profiling (Ribo-seq). This will allow us to identify novel short open reading frames-encoded peptides in RNA regions previously classified as non-coding. By comparing patients and controls, we will detect disease specific expression of annotated and novel peptides, potentially discovering new self-antigens and pep-tides related to triggering autoimmune B and T cell responses that lead to the break of selftolerance, and/or modulation of inflammation and fibrosis. Moreover, by building a single cell atlas we will discern fundamental causes of maladaptive hepatic immune regulation and infer new strategies to limit them.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Professor Dr. Norbert Hübner; Professor Dr. Christoph Schramm
