Mnemonic resources of the mammillary body (A09*)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

The mammillary body (MB) is one of the hippocampus’ main projection targets and plays a major role in the processing of episodic memories. In the early stages of Alzheimer’s disease, hippocampal function deteriorates while the MB remains relatively unaffected. Project A09 aims to unlock potential reserve mechanisms in the MB to improve memory processing in the diseased brain. We already pioneered single-cell in vivo calcium imaging to understand MB mnemonic coding properties. We will use neural activity manipulations to enhance hippocampus–MB functional connectivity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Dr. Oliver Barnstedt; Dr. Anne Petzold