Detailseite
Projekt
Characterization of a hepatocellular carcinoma risk genotype serving as a predictor of recurrence after living donor liver transplantation and its relation to the modulated host milieu observed in the regeneration liver graft
Antragsteller
Privatdozent Dr. Frank Weber
Fachliche Zuordnung
Allgemein- und Viszeralchirurgie
Förderung
Förderung von 2007 bis 2011
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5397027
Erstellungsjahr
2012
Zusammenfassung der Projektergebnisse
The study aim was to identify not only a high-risk hepatocellular carcinoma (HCC) genotype, serving as a predictor for recurrence but more importantly to elucidate the role of the apparently non-malignant remnant liver in HCC recurrence. Furthermore, we set out to characterize the role of HIF-1 and associated pathways on liver regeneration and HCC tumor recurrence. With our observation we contributed to the growing evidence that indeed an altered molecular signature of the apparently non-malignant liver tissue is one of the key mechanisms of HCC recurrence and metastasis.
Projektbezogene Publikationen (Auswahl)
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Deregulation of HIF1-alpha and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue-influence of a modulated host stroma on the prognosis of HCC. Langenbecks Arch Surg. 2010, 395: 395-405
Simon F, Bockhorn M, Praha C, Baba HA, Broelsch CE, Frilling A, Weber F
