Characterization of a hepatocellular carcinoma risk genotype serving as a predictor of recurrence after living donor liver transplantation and its relation to the modulated host milieu observed in the regeneration liver graft

• Applicant: Privatdozent Dr. Frank Weber
• Subject Area: General and Visceral Surgery
• Term: from 2007 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5397027

• Final Report Year: 2012

Final Report Abstract

The study aim was to identify not only a high-risk hepatocellular carcinoma (HCC) genotype, serving as a predictor for recurrence but more importantly to elucidate the role of the apparently non-malignant remnant liver in HCC recurrence. Furthermore, we set out to characterize the role of HIF-1 and associated pathways on liver regeneration and HCC tumor recurrence. With our observation we contributed to the growing evidence that indeed an altered molecular signature of the apparently non-malignant liver tissue is one of the key mechanisms of HCC recurrence and metastasis.

Publications

• Deregulation of HIF1-alpha and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue-influence of a modulated host stroma on the prognosis of HCC. Langenbecks Arch Surg. 2010, 395: 395-405
  Simon F, Bockhorn M, Praha C, Baba HA, Broelsch CE, Frilling A, Weber F
  (See online at https://doi.org/10.1007/s00423-009-0590-9)