Project Details
Characterization of a hepatocellular carcinoma risk genotype serving as a predictor of recurrence after living donor liver transplantation and its relation to the modulated host milieu observed in the regeneration liver graft
Applicant
Privatdozent Dr. Frank Weber
Subject Area
General and Visceral Surgery
Term
from 2007 to 2011
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5397027
Final Report Year
2012
Final Report Abstract
The study aim was to identify not only a high-risk hepatocellular carcinoma (HCC) genotype, serving as a predictor for recurrence but more importantly to elucidate the role of the apparently non-malignant remnant liver in HCC recurrence. Furthermore, we set out to characterize the role of HIF-1 and associated pathways on liver regeneration and HCC tumor recurrence. With our observation we contributed to the growing evidence that indeed an altered molecular signature of the apparently non-malignant liver tissue is one of the key mechanisms of HCC recurrence and metastasis.
Publications
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Deregulation of HIF1-alpha and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue-influence of a modulated host stroma on the prognosis of HCC. Langenbecks Arch Surg. 2010, 395: 395-405
Simon F, Bockhorn M, Praha C, Baba HA, Broelsch CE, Frilling A, Weber F