In vitro Germ Cell Differentiation of Cord-Blood-derived Unrestricted Somatic Stem Cells (USSC)

• Antragsteller: Professor Dr. Hans Robert Schöler
• Fachliche Zuordnung: Hämatologie, Onkologie
• Förderung: Förderung von 2007 bis 2011
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 20803802

Human cord-blood derived unrestricted somatic stem cells (USSC) can be reprogrammed to induced pluripotent stem (iPS) cells. This project derives and characterizes iPS cells from USSC (iP-USSC) by different means. The differentiation potential of reprogrammed cord blood cells will be assessed in comparison to native USSC. The focus of this project embraces mesodermal / hematopoietic and germ cell induction from iP-USSC. Besides reprogramming to full pluripotency induction of mesodermal progenitors in USSC will be evaluated.

• DFG-Verfahren: Forschungsgruppen
• Teilprojekt zu: FOR 717: Unrestricted somatic stem cells from umbilical cord blood (ussc)
• Beteiligte Person: Professor Dr. Tobias Cantz