SFB 1784:  The Interplay of Thrombosis and Inflammation - Translating molecular mechanisms into Clinical applications (InTraC)

• Subject Area: Medicine ; Biology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 560243407

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - Role of TET2-mediated clonal hematopoiesis in thromboinflammation (Project Heads Pircher, Joachim ;  Schulz, Christian )
• A02 - Targeting tissue factor in thromboinflammatory signalling (Project Heads Müller-Calleja, Nadine ;  Ruf, Wolfram )
• A03 - Circadian regulation of immunothrombosis and thromboinflammation (Project Heads Nicolai, Leo ;  Robles, Maria )
• A04 - Translating hibernation-induced thromboprotective mechanisms: from bears to patients (Project Heads Müller-Reif, Johannes Bruno ;  Petzold, Tobias )
• A05 - The role of microbiota-derived tryptophan metabolites in promoting thromboinflammation after stroke (Project Heads Benakis, Corinne ;  Reinhardt, Christoph Ralf )
• A06 - Dissecting and targeting platelet GPIb-V-IX function in thromboinflammation (Project Heads Beck, Sarah ;  Nieswandt, Bernhard )
• A07 - Neutrophils regulate platelet production – impact on cardiovascular and infectious diseases (Project Heads Massberg, Steffen ;  Thienel, Manuela )
• A08 - Directed platelet migration as driver of immunothrombosis (Project Heads Gärtner, Ph.D., Florian ;  Ishikawa-Ankerhold, Hellen )
• B01 - Thromboinflammation at the cerebrovascular interface: linking inflammation and neurological deterioration after stroke (Project Heads Liesz, Arthur ;  Roth, Stefan )
• B02 - Thromboinflammation in stroke: a (reverse)-translational study to identify circulating biomarkers and treatment targets (Project Heads Dichgans, Martin ;  Tiedt, Ph.D., Steffen )
• B03 - The role of Bruton's tyrosine kinase (Btk) in thromboinflammation (Project Heads von Hundelshausen, Philipp ;  Weber, Christian )
• B04 - Stasis-induced endothelial activation and thromboinflammation: implications for atrial fibrillation and venous thrombosis (Project Heads Bochenek, Ph.D., Magdalena ;  Reichart, Daniel )
• B05 - Endothelial cell signalling in thromboinflammation (Project Heads Bikou, Olympia ;  Schäfer, Katrin )
• B06 - Non-classical monocytes as local orchestrators of the thrombotic milieu during the transition from thrombus formation to resolution (Project Heads Pekayvaz, Kami Alexander ;  Steffens, Sabine )
• B07 - Engineering immune cells as micropharmacies for microvascular thrombolysis (Project Heads Kobold, Sebastian ;  Reichel, Christoph )
• B08 - Thromboinflammatory mechanisms of pancreatitis progression and associated splanchnic and portal vein thrombosis (Project Heads Kaiser, Rainer ;  Mayerle, Julia )
• B09 - siRNA therapy targeting endothelial IgM receptors to treat and prevent thromboinflammation (Project Heads Merkel, Olivia Monika ;  Stark, Konstantin )
• MGK - ProTraC: Integrated Research Training Group (Project Heads Ishikawa-Ankerhold, Hellen ;  Stark, Konstantin )
• Z01 - Data integration and analysis service platform for target and biomarker discovery (Project Heads Heinig, Matthias ;  Vieluf, Solveig )
• Z02 - Large animal disease models of immunothrombosis and thromboinflammation for target validation, imaging diagnostics, and therapeutic testing (Project Heads Brendel, Matthias ;  Clauß, Sebastian ;  Merkus, Ph.D., Daphne ;  Werner, Rudolf ;  Wolf, Eckhard )
• Z03 - Central Administration and Coordination (Project Head Massberg, Steffen )

• Applicant Institution: Ludwig-Maximilians-Universität München
• Participating University: Charité - Universitätsmedizin Berlin; Deutsches Herzzentrum der Charité (DHZC); Johannes Gutenberg-Universität Mainz; Julius-Maximilians-Universität Würzburg
• Participating Institution: Helmholtz Zentrum München - ; Deutsches Forschungszentrum für Gesundheit und Umwelt; Computational Health Center; Max-Planck-Institut für Biochemie (MPIB)
• Spokesperson: Professor Dr. Steffen Massberg