Understanding Triazenolysis

• Applicant: Professor Dr. Peter R. Schreiner
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 560955845

This research proposal focuses on advancing the recently revealed triazenolysis reaction, a process that enables the direct synthesis of amines from alkenes via C=C bond cleavage, positioning it as an aza-version of the ubiquitously used ozonolysis reaction. Our computational and experimental studies aim to address unsolved challenges in triazenolysis to broaden its scope, refine selectivity, and improve predictability by means of structural and mechanistic studies. We also plan to develop "constructive" triazenolysis, which not only cleaves alkenes but simultaneously constructs C-N and C-C bonds, facilitating efficient, one-pot synthesis of substituted amines. Building on mechanistic insights, our team aims to extend this knowledge to develop heteroatom-olefin metathesis reactions, which will transform alkenes into motifs containing C-N, C-O, or C-P bonds, contributing synthetic methods for generating valuable amines, alcohols, and phosphines. Through collaborative experimental and computational studies, based on our matching expertise, the research holds promise for significant contributions to organic chemistry by offering new, versatile, and metal-free synthetic transformations.

• DFG Programme: Research Grants
• International Connection: Israel
• Partner Organisation: The Israel Science Foundation
• Cooperation Partner: Dr. Mark Gandelman