Functions of the dynamic ribosomal epitranscriptome in shaping myeloid plasticity (A01)

• Subject Area: Hematology, Oncology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 533056198

Using nanopore sequencing of single native RNA molecules from primary samples project A01 will comprehensively identify AML- associated epitranscriptomic changes in rRNA and its functional consequences for cellular plasticity. Regulators that induce specific rRNA modifications patterns, such as snoRNAs, will be characterized via focused CRISPR screens to identify therapeutic vulnerabilities.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1709: Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Carsten Müller-Tidow