Plastic growth behaviour of patients’ AML in vivo: Releasing dormant cells from their protective niche (A06)

• Subject Area: Hematology, Oncology ; Medical Informatics and Medical Bioinformatics
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 533056198

Using primary patient AML samples, PDX mouse models, single-cell/bulk omics profiling and integrative data analysis A06 will identify the underlying intra- and extra-cellular regulators and regulatory networks responsible for the switch from dormancy to the actively proliferating state of LSCs. Given the reversibility of the plastic phenotype, novel therapeutic approaches to release resistant LSCs from their protective bone marrow environment in order to convert them into treatment-responsive cells shall be investigated by reverse genetics in PDX models in vivo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1709: Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professorin Dr. Irmela Jeremias; Dr. Junyan Lu