Photocontrol of RNA activity using cyclic tethers and red light

• Applicant: Professor Dr. Alexander Heckel
• Subject Area: Biological and Biomimetic Chemistry
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 563505966

Angiogenesis, the formation of new blood vessels, is a critical process in cardiovascular repair, particularly following myocardial infarction. However, systemic upregulation of angiogenesis poses significant risks, underscoring the need for spatial and temporal control. This project aims to achieve targeted red-light regulation of miRNAs 34a and 92a, key regulators of angiogenesis, in cell cultures. We propose to design and synthesize red-light photocleavable, self-immolative linkers allowing a cyclization approach for antimiRs to enhance RNA regulation efficiency. The outcomes of this research will provide a novel framework, which could be potentially used for precise, non-invasive control of angiogenesis, paving the way for innovative therapeutic strategies in cardiovascular medicine.

• DFG Programme: Research Grants
• International Connection: Czech Republic
• Partner Organisation: Czech Science Foundation
• Cooperation Partner: Professor Dr. Petr Klán