Project Details
Projekt
Function and regulation of tissue-resident memory T cells in the female reproductive tract: impact on maternal health during pregnancy (A05)
Subject Area
Reproductive Medicine, Urology
Immunology
Immunology
Term
since 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 534829736
T cell tolerance towards foetal antigens is fundamental for successful pregnancy. The female reproductive tract harbours tissue-resident memory T cells (TRM cells). However, there is only minimal information on the function of these TRM cells during pregnancy. We hypothesise that suppression of uterine TRM cells is essential for foetal tolerance. Failure in their suppression will impair foetal development or lead to foetal rejection. We will employ a pre-clinical mouse model to investigate how activation of TRM cells is controlled during pregnancy and how environmental adversities and maternal immune activation can override this control.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Professor Dr. Hans-Willi Mittrücker; Dr. Kristin Thiele
