Consequences of maternal immune activation on the postnatal responsiveness of foetal haematopoiesis-derived γδ T cells (B06)

• Subject Area: Reproductive Medicine, Urology ; Immunology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 534829736

Gamma-delta T cells develop in the foetal thymus and prepare the body to encounter microbiota and pathogens before, during and after birth. We will apply our experimental mouse systems, novel tools for monitoring human gamma-delta T cells and interdisciplinary collaborations with members of this consortium to test the hypothesis that maternal immune activation (MIA) disrupts the prenatal development of gamma-delta T cells and affects gamma-delta T cell composition and function postnatally.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1713: Maternal Immune Activation: Causes and Consequences
• Applicant Institution: Universität Hamburg
• Project Heads: Professor Dr. Immo Prinz; Professorin Dr. Sarina Ravens