Role of lymphocyte innate sensors in MASLD/MASH development (B06)

• Subject Area: Gastroenterology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 535081457

Sensing hepatic cellular stress is a central event in the progression of metabolic dysfunction-associated fatty liver disease (MASLD). However, the role of lymphocyte innate sensors in mediating this process remains unclear. By using a combination of multi-omics analyses along with genetic mouse models, we will assess the molecular mechanisms driving the upregulation of stress ligands, define the function of lymphocyte innate sensors and evaluate their impact on modulating MASLD. Our findings will provide a comprehensive picture of how lymphocyte sensors contribute to MASLD inflammation and progression and how this might provide novel opportunities for therapeutic interventions.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 412: Metabolic dysfunction-associated steatotic liver disease: Translating mechanisms to tailored therapeutic concepts
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professorin Dr. Chiara Romagnani, Ph.D.; Dr. Christina Stehle