Specific role(s) of the inflammasome in the TME of primary and metastasized sporadic CRC (P07)

• Subject Area: Gastroenterology ; Immunology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 540805631

The project will specifically examine the contribution of inflammasomes that act as intracellular danger-sensing complex controlling release of pro-inflammatory cytokines belonging to the IL-1 family. Various genetic models targeting specific inflammasome components in different cell types will be explored to determine their exact contribution to the metastatic cascade. Moreover, this project will provide a comprehensive functional analysis of specific triggers and downstream effects of the inflammasome in a cell type specific manner in the TME during metastasis formation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 417: Cellular Communication in the Stroma of Colorectal Cancer: From Pathophysiology to Clinical Translation
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Dr. Christopher Berlin, Ph.D.; Professor Dr. Olaf Groß