Heterogeneity of MASLD – biobanking and clinical phenotyping of MASLD (Z01)

• Subject Area: Gastroenterology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 535081457

The consideration of heterogeneity of metabolic dysfunction-associated fatty liver disease (MASLD) is mandatory to precisely define the natural history of different MASLD phenotypes and to appropriately select for specific research questions and clinical trials. We will provide a variety of longitudinally collected adult and pediatric human MASLD samples to the entire CRC/TR. The detailed clinical characterization in combination with the molecular characterization in the projects of the CRC/TR will allow an extensive phenotyping and the identification of new sub-phenotypes, which can guide the development of better preclinical models and identify novel phenotype-targeted therapies.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 412: Metabolic dysfunction-associated steatotic liver disease: Translating mechanisms to tailored therapeutic concepts
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professorin Dr. Münevver Demir; Professor Dr. Nikolaos Perakakis; Professor Dr. Igor Maximilian Sauer